Marius K. Lemberg
Marius K. Lemberg
Center for Biochemistry, Medical Faculty, University of Cologne
Verifisert e-postadresse på uni-koeln.de - Startside
Sitert av
Sitert av
Intramembrane proteolysis promotes trafficking of hepatitis C virus core protein to lipid droplets
J McLauchlan, MK Lemberg, G Hope, B Martoglio
The EMBO journal, 2002
Identification of signal peptide peptidase, a presenilin-type aspartic protease
A Weihofen, K Binns, MK Lemberg, K Ashman, B Martoglio
Science 296 (5576), 2215-2218, 2002
The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking
C Meissner, H Lorenz, A Weihofen, DJ Selkoe, MK Lemberg
Journal of neurochemistry 117 (5), 856-867, 2011
Requirements for signal peptide peptidase-catalyzed intramembrane proteolysis
MK Lemberg, B Martoglio
Molecular cell 10 (4), 735-744, 2002
Functional and evolutionary implications of enhanced genomic analysis of rhomboid intramembrane proteases
MK Lemberg, M Freeman
Genome research 17 (11), 1634-1646, 2007
Proteolytic ectodomain shedding of membrane proteins in mammals—hardware, concepts, and recent developments
SF Lichtenthaler, MK Lemberg, R Fluhrer
The EMBO journal 37 (15), e99456, 2018
Intramembrane proteolysis of signal peptides: an essential step in the generation of HLA-E epitopes
MK Lemberg, FA Bland, A Weihofen, VM Braud, B Martoglio
The Journal of Immunology 167 (11), 6441-6446, 2001
Ubiquitin-dependent intramembrane rhomboid protease promotes ERAD of membrane proteins
L Fleig, N Bergbold, P Sahasrabudhe, B Geiger, L Kaltak, MK Lemberg
Molecular cell 47 (4), 558-569, 2012
Mechanism of intramembrane proteolysis investigated with purified rhomboid proteases
MK Lemberg, J Menendez, A Misik, M Garcia, CM Koth, M Freeman
The EMBO journal 24 (3), 464-472, 2005
Release of signal peptide fragments into the cytosol requires cleavage in the transmembrane region by a protease activity that is specifically blocked by a novel cysteine …
A Weihofen, MK Lemberg, HL Ploegh, M Bogyo, B Martoglio
Journal of Biological Chemistry 275 (40), 30951-30956, 2000
Targeting presenilin-type aspartic protease signal peptide peptidase with γ-secretase inhibitors
A Weihofen, MK Lemberg, E Friedmann, H Rueeger, A Schmitz, ...
Journal of Biological Chemistry 278 (19), 16528-16533, 2003
Human cytomegalovirus UL40 signal peptide regulates cell surface expression of the NK cell ligands HLA-E and gpUL18
V Prod’homme, P Tomasec, C Cunningham, MK Lemberg, RJ Stanton, ...
The Journal of Immunology 188 (6), 2794-2804, 2012
Mammalian EGF receptor activation by the rhomboid protease RHBDL2
C Adrain, K Strisovsky, M Zettl, L Hu, MK Lemberg, M Freeman
EMBO reports 12 (5), 421-427, 2011
Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins
E Friedmann, MK Lemberg, A Weihofen, KK Dev, U Dengler, G Rovelli, ...
Journal of Biological Chemistry 279 (49), 50790-50798, 2004
Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP 1u
C Chen, NS Malchus, B Hehn, W Stelzer, D Avci, D Langosch, ...
The EMBO journal 33 (21), 2492-2506, 2014
Understanding intramembrane proteolysis: from protein dynamics to reaction kinetics
D Langosch, C Scharnagl, H Steiner, MK Lemberg
Trends in biochemical sciences 40 (6), 318-327, 2015
Post-targeting functions of signal peptides
K Kapp, S Schrempf, MK Lemberg, B Dobberstein
Protein transport into the endoplasmic reticulum 1, 1-16, 2009
Intramembrane protease PARL defines a negative regulator of PINK1-and PARK2/Parkin-dependent mitophagy
C Meissner, H Lorenz, B Hehn, MK Lemberg
Autophagy 11 (9), 1484-1498, 2015
Clipping or extracting: two ways to membrane protein degradation
D Avci, MK Lemberg
Trends in cell biology 25 (10), 611-622, 2015
Cooperation of mitochondrial and ER factors in quality control of tail-anchored proteins
V Dederer, A Khmelinskii, AG Huhn, V Okreglak, M Knop, MK Lemberg
elife 8, e45506, 2019
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