| Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer B Chen, ME Dodge, W Tang, J Lu, Z Ma, CW Fan, S Wei, W Hao, J Kilgore, ... Nature chemical biology 5 (2), 100-107, 2009 | 1593 | 2009 |
| The Hedgehog response network: sensors, switches, and routers L Lum, PA Beachy science 304 (5678), 1755-1759, 2004 | 1027 | 2004 |
| Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells L Lum, S Yao, B Mozer, A Rovescalli, D Von Kessler, M Nirenberg, ... Science 299 (5615), 2039-2045, 2003 | 646 | 2003 |
| Minimizing the risk of reporting false positives in large-scale RNAi screens CJ Echeverri, PA Beachy, B Baum, M Boutros, F Buchholz, SK Chanda, ... Nature methods 3 (10), 777-779, 2006 | 598 | 2006 |
| Evidence for a role of a tumor necrosis factor-α (TNF-α)-converting enzyme-like protease in shedding of TRANCE, a TNF family member involved in osteoclastogenesis and dendritic … L Lum, BR Wong, R Josien, JD Becherer, H Erdjument-Bromage, ... Journal of Biological Chemistry 274 (19), 13613-13618, 1999 | 590 | 1999 |
| Prevalence of off-target effects in Drosophila RNA interference screens Y Ma, A Creanga, L Lum, PA Beachy Nature 443 (7109), 359-363, 2006 | 354 | 2006 |
| Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development CM Karner, A Das, Z Ma, M Self, C Chen, L Lum, G Oliver, TJ Carroll Development 138 (7), 1247-1257, 2011 | 306 | 2011 |
| Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2 L Lum, C Zhang, S Oh, RK Mann, DP Von Kessler, J Taipale, ... Molecular cell 12 (5), 1261-1274, 2003 | 294 | 2003 |
| The ihog cell-surface proteins bind Hedgehog and mediate pathway activation S Yao, L Lum, P Beachy Cell 125 (2), 343-357, 2006 | 280 | 2006 |
| In vivo Wnt signaling tracing through a transgenic biosensor fish reveals novel activity domains E Moro, G Ozhan-Kizil, A Mongera, D Beis, C Wierzbicki, RM Young, ... Developmental biology 366 (2), 327-340, 2012 | 248 | 2012 |
| Intracellular maturation of the mouse metalloprotease disintegrin MDC15 L Lum, MS Reid, CP Blobel Journal of Biological Chemistry 273 (40), 26236-26247, 1998 | 237 | 1998 |
| Metargidin, a Membrane-anchored Metalloprotease-Disintegrin Protein with an RGD Integrin Binding Sequence (∗) J Krätzschmar, L Lum, CP Blobel Journal of Biological Chemistry 271 (9), 4593-4596, 1996 | 236 | 1996 |
| Stromal–epithelial crosstalk regulates kidney progenitor cell differentiation A Das, S Tanigawa, CM Karner, M Xin, L Lum, C Chen, EN Olson, ... Nature cell biology 15 (9), 1035-1044, 2013 | 235 | 2013 |
| Potential role for ADAM15 in pathological neovascularization in mice K Horiuchi, G Weskamp, L Lum, HP Hammes, H Cai, TA Brodie, T Ludwig, ... Molecular and cellular biology 23 (16), 5614-5624, 2003 | 221 | 2003 |
| Extensive phosphorylation of Smoothened in Hedgehog pathway activation C Zhang, EH Williams, Y Guo, L Lum, PA Beachy Proceedings of the National Academy of Sciences 101 (52), 17900-17907, 2004 | 220 | 2004 |
| A genome-wide RNAi screen for Wnt/β-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer W Tang, M Dodge, D Gundapaneni, C Michnoff, M Roth, L Lum Proceedings of the National Academy of Sciences 105 (28), 9697-9702, 2008 | 206 | 2008 |
| Evidence for a critical role of the tumor necrosis factor α convertase (TACE) in ectodomain shedding of the p75 neurotrophin receptor (p75NTR) G Weskamp, J Schlöndorff, L Lum, JD Becherer, TW Kim, P Saftig, ... Journal of Biological Chemistry 279 (6), 4241-4249, 2004 | 202 | 2004 |
| CRISPR-Cas9-based mutagenesis frequently provokes on-target mRNA misregulation R Tuladhar, Y Yeu, J Tyler Piazza, Z Tan, J Rene Clemenceau, X Wu, ... Nature communications 10 (1), 4056, 2019 | 196 | 2019 |
| Small molecule Wnt inhibitors enhance the efficiency of BMP-4-directed cardiac differentiation of human pluripotent stem cells Y Ren, MY Lee, S Schliffke, J Paavola, PJ Amos, X Ge, M Ye, S Zhu, ... Journal of molecular and cellular cardiology 51 (3), 280-287, 2011 | 188 | 2011 |
| Biochemical and pharmacological criteria define two shedding activities for TRANCE/OPGL that are distinct from the tumor necrosis factor α convertase J Schlöndorff, L Lum, CP Blobel Journal of Biological Chemistry 276 (18), 14665-14674, 2001 | 161 | 2001 |
