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Erik Sontheimer
Erik Sontheimer
RNA Therapeutics Institute, UMass Medical School
Verifisert e-postadresse på umassmed.edu
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Origins and mechanisms of miRNAs and siRNAs
RW Carthew, EJ Sontheimer
Cell 136 (4), 642-655, 2009
59372009
CRISPR interference limits horizontal gene transfer in staphylococci by targeting DNA
LA Marraffini, EJ Sontheimer
science 322 (5909), 1843-1845, 2008
20472008
Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways
YS Lee, K Nakahara, JW Pham, K Kim, Z He, EJ Sontheimer, RW Carthew
Cell 117 (1), 69-81, 2004
16872004
CRISPR interference: RNA-directed adaptive immunity in bacteria and archaea
LA Marraffini, EJ Sontheimer
Nature Reviews Genetics 11 (3), 181-190, 2010
12622010
Self versus non-self discrimination during CRISPR RNA-directed immunity
LA Marraffini, EJ Sontheimer
Nature 463 (7280), 568-571, 2010
9082010
Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis
Z Hou, Y Zhang, NE Propson, SE Howden, LF Chu, EJ Sontheimer, ...
Proceedings of the National Academy of Sciences 110 (39), 15644-15649, 2013
8602013
Assembly and function of RNA silencing complexes
EJ Sontheimer
Nature Reviews Molecular Cell Biology 6 (2), 127-138, 2005
6022005
A Dicer-2-dependent 80s complex cleaves targeted mRNAs during RNAi in Drosophila
JW Pham, JL Pellino, YS Lee, RW Carthew, EJ Sontheimer
Cell 117 (1), 83-94, 2004
5772004
Target DNA interference with crRNA
EJ Sontheimer, LA Marraffini
US Patent App. 12/565,589, 2010
5522010
The U5 and U6 small nuclear RNAs as active site components of the spliceosome
EJ Sontheimer, JA Steitz
Science 262 (5142), 1989-1996, 1993
5301993
Site-specific cross-linking of mammalian U5 snRNP to the 5'splice site before the first step of pre-mRNA splicing.
JR Wyatt, EJ Sontheimer, JA Steitz
Genes & Development 6 (12b), 2542-2553, 1992
4131992
Naturally occurring off-switches for CRISPR-Cas9
A Pawluk, N Amrani, Y Zhang, B Garcia, Y Hidalgo-Reyes, J Lee, A Edraki, ...
Cell 167 (7), 1829-1838. e9, 2016
4072016
Silence from within: endogenous siRNAs and miRNAs
EJ Sontheimer, RW Carthew
Cell 122 (1), 9-12, 2005
3732005
Silencing by small RNAs is linked to endosomal trafficking
YS Lee, S Pressman, AP Andress, K Kim, JL White, JJ Cassidy, X Li, ...
Nature cell biology 11 (9), 1150-1156, 2009
3712009
Processing-independent CRISPR RNAs limit natural transformation in Neisseria meningitidis
Y Zhang, N Heidrich, BJ Ampattu, CW Gunderson, HS Seifert, C Schoen, ...
Molecular cell 50 (4), 488-503, 2013
3692013
Adenovirus-Mediated Somatic Genome Editing of Pten by CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses
D Wang, H Mou, S Li, Y Li, S Hough, K Tran, J Li, H Yin, DG Anderson, ...
Human gene therapy 26 (7), 432-442, 2015
3672015
A broad-spectrum inhibitor of CRISPR-Cas9
LB Harrington, KW Doxzen, E Ma, JJ Liu, GJ Knott, A Edraki, B Garcia, ...
Cell 170 (6), 1224-1233. e15, 2017
2552017
Metal ion catalysis during splicing of premessenger RNA
EJ Sontheimer, S Sun, JA Piccirilli
Nature 388 (6644), 801-805, 1997
2511997
A compact, high-accuracy Cas9 with a dinucleotide PAM for in vivo genome editing
A Edraki, A Mir, R Ibraheim, I Gainetdinov, Y Yoon, CQ Song, Y Cao, ...
Molecular cell 73 (4), 714-726. e4, 2019
2012019
Metal ion catalysis during the exon-ligation step of nuclear pre-mRNA splicing: extending the parallels between the spliceosome and group II introns.
PM Gordon, EJ Sontheimer, JA Piccirilli
Rna 6 (2), 199-205, 2000
1882000
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Artikler 1–20