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Stefano Morotti
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FRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility
NC Surdo, M Berrera, A Koschinski, M Brescia, MR Machado, C Carr, ...
Nature communications 8 (1), 15031, 2017
1992017
A computational model of induced pluripotent stem‐cell derived cardiomyocytes incorporating experimental variability from multiple data sources
DC Kernik, S Morotti, HD Wu, P Garg, HJ Duff, J Kurokawa, J Jalife, ...
The Journal of physiology 597 (17), 4533-4564, 2019
1152019
Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes
MA Nystoriak, M Nieves-Cintrón, T Patriarchi, OR Buonarati, MP Prada, ...
Science signaling 10 (463), eaaf9647, 2017
1132017
A novel computational model of mouse myocyte electrophysiology to assess the synergy between Na+ loading and CaMKII
S Morotti, AG Edwards, AD McCulloch, DM Bers, E Grandi
The Journal of physiology 592 (6), 1181-1197, 2014
1112014
Trafficking Defects and Gating Abnormalities of a Novel SCN5A Mutation Question Gene-Specific Therapy in Long QT Syndrome Type 3
Y Ruan, M Denegri, N Liu, T Bachetti, M Seregni, S Morotti, S Severi, ...
Circulation research 106 (8), 1374-1383, 2010
1102010
General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy
Z Li, GR Mirams, T Yoshinaga, BJ Ridder, X Han, JE Chen, ...
Clinical Pharmacology & Therapeutics 107 (1), 102-111, 2020
762020
A heart for diversity: simulating variability in cardiac arrhythmia research
H Ni, S Morotti, E Grandi
Frontiers in physiology 9, 958, 2018
742018
Ca2+ current facilitation is CaMKII-dependent and has arrhythmogenic consequences
DM Bers, S Morotti
Frontiers in pharmacology 5, 144, 2014
722014
β-adrenergic effects on cardiac myofilaments and contraction in an integrated rabbit ventricular myocyte model
JA Negroni, S Morotti, EC Lascano, AV Gomes, E Grandi, JL Puglisi, ...
Journal of molecular and cellular cardiology 81, 162-175, 2015
642015
Hypokalemia promotes arrhythmia by distinct mechanisms in atrial and ventricular myocytes
K Tazmini, M Frisk, M Laasmaa, A Lewalle, S Morotti, DB Lipsett, ...
Biophysical Journal 118 (3), 103a, 2020
572020
Theoretical study of L‐type Ca2+ current inactivation kinetics during action potential repolarization and early afterdepolarizations
S Morotti, E Grandi, A Summa, KS Ginsburg, DM Bers
The Journal of physiology 590 (18), 4465-4481, 2012
572012
Logistic regression analysis of populations of electrophysiological models to assess proarrythmic risk
S Morotti, E Grandi
MethodsX 4, 25-34, 2017
542017
Atrial-selective targeting of arrhythmogenic phase-3 early afterdepolarizations in human myocytes
S Morotti, AD McCulloch, DM Bers, AG Edwards, E Grandi
Journal of Molecular and Cellular Cardiology 96, 63-71, 2016
512016
Quantitative analysis of the Ca2+‐dependent regulation of delayed rectifier K+ current IKs in rabbit ventricular myocytes
DC Bartos, S Morotti, KS Ginsburg, E Grandi, DM Bers
The Journal of physiology 595 (7), 2253-2268, 2017
482017
Adenylyl cyclase 5–generated cAMP controls cerebral vascular reactivity during diabetic hyperglycemia
AU Syed, GR Reddy, D Ghosh, MP Prada, MA Nystoriak, S Morotti, ...
The Journal of clinical investigation 129 (8), 3140-3152, 2019
462019
Interplay of voltage and Ca-dependent inactivation of L-type Ca current
E Grandi, S Morotti, KS Ginsburg, S Severi, DM Bers
Progress in biophysics and molecular biology 103 (1), 44-50, 2010
442010
CaMKIIδC Drives Early Adaptive Ca2+ Change and Late Eccentric Cardiac Hypertrophy
S Ljubojevic-Holzer, AW Herren, N Djalinac, J Voglhuber, S Morotti, ...
Circulation research 127 (9), 1159-1178, 2020
402020
Enhanced depolarization drive in failing rabbit ventricular myocytes: calcium-dependent and β-adrenergic effects on late sodium, L-type calcium, and sodium-calcium exchange …
B Hegyi, S Morotti, C Liu, KS Ginsburg, J Bossuyt, L Belardinelli, LT Izu, ...
Circulation: Arrhythmia and Electrophysiology 12 (3), e007061, 2019
342019
Inward rectifier potassium channels (Kir2. x) and caveolin-3 domain–specific interaction: implications for purkinje cell–dependent ventricular arrhythmias
R Vaidyanathan, H Van Ert, KT Haq, S Morotti, S Esch, EC McCune, ...
Circulation: Arrhythmia and Electrophysiology 11 (1), e005800, 2018
332018
Quantitative cross-species translators of cardiac myocyte electrophysiology: Model training, experimental validation, and applications
S Morotti, C Liu, B Hegyi, H Ni, A Fogli Iseppe, L Wang, M Pritoni, ...
Science Advances 7 (47), eabg0927, 2021
302021
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