|Detecting chromatin interactions between and along sister chromatids with SisterC|
ME Oomen, AK Hedger, JK Watts, J Dekker
Nature Methods 17 (10), 1002-1009, 2020
|Avoiding Drug Resistance by Substrate Envelope-Guided Design: Toward Potent and Robust HCV NS3/4A Protease Inhibitors|
AN Matthew, J Zephyr, DN Rao, M Henes, W Kamran, K Kosovrasti, ...
mBio 11 (2), 2020
|Discovery of Quinoxaline-Based P1–P3 Macrocyclic NS3/4A Protease Inhibitors with Potent Activity against Drug-Resistant Hepatitis C Virus Variants|
D Nageswara Rao, J Zephyr, M Henes, ET Chan, AN Matthew, ...
Journal of Medicinal Chemistry 64 (16), 11972-11989, 2021
|Deciphering the Molecular Mechanism of HCV Protease Inhibitor Fluorination as a General Approach to Avoid Drug Resistance|
J Zephyr, DN Rao, SV Vo, M Henes, K Kosovrasti, AN Matthew, ...
Journal of Molecular Biology 434 (9), 167503, 2022
|Progress toward an amplifiable metabolic label for DNA: conversion of 4-thiothymidine (4sT) to 5-methyl-2′-deoxycytidine and synthesis of a 4sT phosphorodiamidate prodrug|
AK Hedger, ME Oomen, V Liu, MP Moazami, N Rhind, J Dekker, JK Watts
Canadian Journal of Chemistry 96 (7), 636-645, 2018
|Structure of the catalytically active APOBEC3G bound to a DNA oligonucleotide inhibitor reveals tetrahedral geometry of the transition state|
A Maiti, AK Hedger, W Myint, V Balachandran, JK Watts, CA Schiffer, ...
Nature Communications 13 (1), 7117, 2022
|Formamide significantly enhances the efficiency of chemical adenylation of RNA sequencing ligation adaptors|
SR Hildebrand, AK Hedger, K Yamada, JK Watts, A Khvorova
RNA 29 (7), 1077-1083, 2023
|Double Click: Unexpected 1: 2 Stoichiometry in a Norbornene–Tetrazine Reaction|
G Devi, AK Hedger, RJ Whitby, JK Watts
The Journal of Organic Chemistry 88 (9), 5341-5347, 2023