Rational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in the CNS ME Østergaard, AL Southwell, H Kordasiewicz, AT Watt, NH Skotte, ... Nucleic acids research 41 (21), 9634-9650, 2013 | 174 | 2013 |
In vivo evaluation of candidate allele-specific mutant huntingtin gene silencing antisense oligonucleotides AL Southwell, NH Skotte, HB Kordasiewicz, ME Østergaard, AT Watt, ... Molecular Therapy 22 (12), 2093-2106, 2014 | 151 | 2014 |
Synthesis and biological evaluation of novel pyrazolyl-2, 4-thiazolidinediones as anti-inflammatory and neuroprotective agents AM Youssef, MS White, EB Villanueva, IM El-Ashmawy, A Klegeris Bioorganic & medicinal chemistry 18 (5), 2019-2028, 2010 | 136 | 2010 |
A fully humanized transgenic mouse model of Huntington disease AL Southwell, SC Warby, JB Carroll, CN Doty, NH Skotte, W Zhang, ... Human molecular genetics 22 (1), 18-34, 2013 | 124 | 2013 |
Huntingtin suppression restores cognitive function in a mouse model of Huntington’s disease AL Southwell, HB Kordasiewicz, D Langbehn, NH Skotte, MP Parsons, ... Science translational medicine 10 (461), eaar3959, 2018 | 109 | 2018 |
Ultrasensitive measurement of huntingtin protein in cerebrospinal fluid demonstrates increase with Huntington disease stage and decrease following brain huntingtin suppression AL Southwell, SEP Smith, TR Davis, NS Caron, EB Villanueva, Y Xie, ... Scientific reports 5 (1), 12166, 2015 | 108 | 2015 |
An enhanced Q175 knock-in mouse model of Huntington disease with higher mutant huntingtin levels and accelerated disease phenotypes AL Southwell, A Smith-Dijak, C Kay, M Sepers, EB Villanueva, ... Human molecular genetics 25 (17), 3654-3675, 2016 | 105 | 2016 |
Anti-semaphorin 4D immunotherapy ameliorates neuropathology and some cognitive impairment in the YAC128 mouse model of Huntington disease AL Southwell, S Franciosi, EB Villanueva, Y Xie, LA Winter, ... Neurobiology of disease 76, 46-56, 2015 | 101 | 2015 |
Mitochondrial transcription factor A (Tfam) is a pro-inflammatory extracellular signaling molecule recognized by brain microglia JP Little, S Simtchouk, SM Schindler, EB Villanueva, NE Gill, DG Walker, ... Molecular and Cellular Neuroscience 60, 88-96, 2014 | 77 | 2014 |
Synthesis and biological evaluation of novel pyrazole compounds AM Youssef, EG Neeland, EB Villanueva, MS White, IM El-Ashmawy, ... Bioorganic & medicinal chemistry 18 (15), 5685-5696, 2010 | 49 | 2010 |
A novel humanized mouse model of Huntington disease for preclinical development of therapeutics targeting mutant huntingtin alleles AL Southwell, NH Skotte, EB Villanueva, ME Østergaard, X Gu, ... Human Molecular Genetics 26 (6), 1115-1132, 2017 | 37 | 2017 |
Secreted phospholipase A2 group IIA is a neurotoxin released by stimulated human glial cells EB Villanueva, JP Little, G Lambeau, A Klegeris Molecular and Cellular Neuroscience 49 (4), 430-438, 2012 | 26 | 2012 |
HACE1 is essential for astrocyte mitochondrial function and influences Huntington disease phenotypes in vivo DE Ehrnhoefer, AL Southwell, M Sivasubramanian, X Qiu, EB Villanueva, ... Human molecular genetics 27 (2), 239-253, 2018 | 25 | 2018 |
Cultured adult porcine astrocytes and microglia express functional interferon-γ receptors and exhibit toxicity towards SH-SY5Y cells VA Ionescu, EB Villanueva, S Hashioka, M Bahniwal, A Klegeris Brain research bulletin 84 (3), 244-251, 2011 | 12 | 2011 |
Moderate increase in temperature may exacerbate neuroinflammatory processes in the brain: Human cell culture studies M Bahniwal, EB Villanueva, A Klegeris Journal of neuroimmunology 233 (1-2), 65-72, 2011 | 11 | 2011 |
Neuronal TNFα, Not α‐Syn, Underlies PDD‐Like Disease Progression in IFNβ‐KO Mice EB Villanueva, E Tresse, Y Liu, JN Duarte, G Jimenez‐Duran, P Ejlerskov, ... Annals of Neurology 90 (5), 789-807, 2021 | 1 | 2021 |
I09 Antibodies inhibit cell to cell transmission of mutant HTT S Bartl, A Oueslati, AL Southwell, M Parth, N Salhat, A Siddu, M Burkert, ... Journal of Neurology, Neurosurgery & Psychiatry 89 (Suppl 1), A91-A91, 2018 | 1 | 2018 |
Therapeutic potential of cannabinoids in the treatment of neuroinflammation associated with Parkinson’s disease EB Villanueva, JP Little, A Klegeris Recent Adv Med Chem 2, 59-75, 2015 | 1 | 2015 |
696. Pre-clinical evaluation of allele-specific mutant huntingtin gene silencing antisense oligonucleotides AL Southwell, NH Skotte, N Caron, H Kordasiewicz, M Oestergaard, ... Molecular Therapy 23, S277, 2015 | 1 | 2015 |
Characterizing the role of secretory phospholipase A₂ group IIA in glial cell-mediated neurotoxicity EB Villanueva University of British Columbia, 2011 | | 2011 |