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Simak Ali
Simak Ali
Professor of Molecular Endocrine Oncology
Verifisert e-postadresse på imperial.ac.uk - Startside
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Differential oestrogen receptor binding is associated with clinical outcome in breast cancer
CS Ross-Innes, R Stark, AE Teschendorff, KA Holmes, HR Ali, ...
Nature 481 (7381), 389-393, 2012
19282012
Mechanisms of tamoxifen resistance: increased estrogen receptor-HER2/neu cross-talk in ER/HER2–positive breast cancer
J Shou, S Massarweh, CK Osborne, AE Wakeling, S Ali, H Weiss, R Schiff
Journal of the National Cancer Institute 96 (12), 926-935, 2004
14982004
Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor α: a new model for anti-estrogen resistance
RA Campbell, P Bhat-Nakshatri, NM Patel, D Constantinidou, S Ali, ...
Journal of Biological Chemistry 276 (13), 9817-9824, 2001
12762001
Endocrine-responsive breast cancer and strategies for combating resistance
S Ali, RC Coombes
Nature Reviews Cancer 2 (2), 101-112, 2002
11392002
Modulation of transcriptional activation by ligand‐dependent phosphorylation of the human oestrogen receptor A/B region.
S Ali, D Metzger, JM Bornert, P Chambon
The EMBO journal 12 (3), 1153-1160, 1993
6161993
Trichostatin A Is a Histone Deacetylase Inhibitor with Potent Antitumor Activity against Breast Cancer in Vivo
DM Vigushin, S Ali, PE Pace, N Mirsaidi, K Ito, I Adcock, RC Coombes
Clinical Cancer Research 7 (4), 971-976, 2001
5832001
Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer
SA Eccles, EO Aboagye, S Ali, AS Anderson, J Armes, F Berditchevski, ...
Breast Cancer Research 15 (5), 1-37, 2013
5002013
Human estrogen receptor β binds DNA in a manner similar to and dimerizes with estrogen receptor α
P Pace, J Taylor, S Suntharalingam, RC Coombes, S Ali
Journal of Biological Chemistry 272 (41), 25832-25838, 1997
4391997
Estrogen receptor alpha in human breast cancer: occurrence and significance
S Ali, RC Coombes
Journal of mammary gland biology and neoplasia 5, 271-281, 2000
4202000
Regulation of ERBB2 by oestrogen receptor–PAX2 determines response to tamoxifen
A Hurtado, KA Holmes, TR Geistlinger, IR Hutcheson, RI Nicholson, ...
Nature 456 (7222), 663-666, 2008
4102008
Enhanced estrogen receptor (ER) α, ERBB2, and MAPK signal transduction pathways operate during the adaptation of MCF-7 cells to long term estrogen deprivation
LA Martin, I Farmer, SRD Johnston, S Ali, C Marshall, M Dowsett
Journal of Biological Chemistry 278 (33), 30458-30468, 2003
3712003
Phosphorylation of human estrogen receptor α by protein kinase A regulates dimerization
D Chen, PE Pace, RC Coombes, S Ali
Molecular and cellular biology 19 (2), 1002-1015, 1999
3651999
Activation of estrogen receptor α by S118 phosphorylation involves a ligand-dependent interaction with TFIIH and participation of CDK7
D Chen, T Riedl, E Washbrook, PE Pace, RC Coombes, JM Egly, S Ali
Molecular cell 6 (1), 127-137, 2000
3642000
Personalized detection of circulating tumor DNA antedates breast cancer metastatic recurrence
RC Coombes, K Page, R Salari, RK Hastings, A Armstrong, S Ahmed, ...
Clinical Cancer Research 25 (14), 4255-4263, 2019
3632019
Characterization of the Amino-terminal Transcriptional Activation Function of the Human Estrogen Receptor in Animal and Yeast Cells (∗)
D Metzger, S Ali, JM Bornert, P Chambon
Journal of Biological Chemistry 270 (16), 9535-9542, 1995
3141995
Phosphorylation of human estrogen receptor α at serine 118 by two distinct signal transduction pathways revealed by phosphorylation-specific antisera
D Chen, E Washbrook, N Sarwar, GJ Bates, PE Pace, ...
Oncogene 21 (32), 4921-4931, 2002
3072002
Mutation analysis of cell-free DNA and single circulating tumor cells in metastatic breast cancer patients with high circulating tumor cell counts
JA Shaw, DS Guttery, A Hills, D Fernandez-Garcia, K Page, BM Rosales, ...
Clinical Cancer Research 23 (1), 88-96, 2017
2182017
Preoperative gefitinib versus gefitinib and anastrozole in postmenopausal patients with oestrogen-receptor positive and epidermal-growth-factor-receptor-positive primary breast …
A Polychronis, HD Sinnett, D Hadjiminas, H Singhal, JL Mansi, ...
The lancet oncology 6 (6), 383-391, 2005
2162005
Phosphorylation at serines 104 and 106 by Erk1/2 MAPK is important for estrogen receptor-α activity
RS Thomas, N Sarwar, F Phoenix, RC Coombes, S Ali
Journal of molecular endocrinology 40 (3), 173, 2008
1892008
Noninvasive Detection of Activating Estrogen Receptor 1 (ESR1) Mutations in Estrogen Receptor–Positive Metastatic Breast Cancer
DS Guttery, K Page, A Hills, L Woodley, SD Marchese, B Rghebi, ...
Clinical chemistry 61 (7), 974-982, 2015
1822015
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