Yu Amanda Guo
Yu Amanda Guo
Genome Institute of Singapore
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Mutation hotspots at CTCF binding sites coupled to chromosomal instability in gastrointestinal cancers
YA Guo, MM Chang, W Huang, WF Ooi, M Xing, P Tan, AJ Skanderup
Nature communications 9 (1), 1520, 2018
Single-cell and bulk transcriptome sequencing identifies two epithelial tumor cell states and refines the consensus molecular classification of colorectal cancer
I Joanito, P Wirapati, N Zhao, Z Nawaz, G Yeo, F Lee, CLP Eng, ...
Nature genetics 54 (7), 963-975, 2022
Developmental plasticity is bound by pluripotency and the Fgf and Wnt signaling pathways
SA Morris, Y Guo, M Zernicka-Goetz
Cell reports 2 (4), 756-765, 2012
Wnt1 silences chemokine genes in dendritic cells and induces adaptive immune resistance in lung adenocarcinoma
D Kerdidani, P Chouvardas, AR Arjo, I Giopanou, G Ntaliarda, YA Guo, ...
Nature communications 10 (1), 1405, 2019
Tissue-specific cell-free DNA degradation quantifies circulating tumor DNA burden
G Zhu, YA Guo, D Ho, P Poon, ZW Poh, PM Wong, A Gan, MM Chang, ...
Nature communications 12 (1), 2229, 2021
Dissecting disease inheritance modes in a three-dimensional protein network challenges the “guilt-by-association” principle
Y Guo, X Wei, J Das, A Grimson, SM Lipkin, AG Clark, H Yu
The American Journal of Human Genetics 93 (1), 78-89, 2013
Pan-Cancer Analysis of Ligand–Receptor Cross-talk in the Tumor Microenvironment
U Ghoshdastider, N Rohatgi, M Mojtabavi Naeini, P Baruah, E Revkov, ...
Cancer research 81 (7), 1802-1812, 2021
Integrated paired-end enhancer profiling and whole-genome sequencing reveals recurrent CCNE1 and IGF2 enhancer hijacking in primary gastric adenocarcinoma
WF Ooi, AM Nargund, KJ Lim, S Zhang, M Xing, A Mandoli, JQ Lim, ...
Gut 69 (6), 1039-1052, 2020
Heritability and inter-population differences in lipid profiles of Drosophila melanogaster
CJF Scheitz, Y Guo, AM Early, LG Harshman, AG Clark
PLoS One 8 (8), e72726, 2013
Whole-genome noncoding sequence analysis in T-cell acute lymphoblastic leukemia identifies oncogene enhancer mutations
S Hu, M Qian, H Zhang, Y Guo, J Yang, X Zhao, H He, J Lu, J Pan, ...
Blood, The Journal of the American Society of Hematology 129 (24), 3264-3268, 2017
Exploring mechanisms of human disease through structurally resolved protein interactome networks
J Das, R Fragoza, HR Lee, NA Cordero, Y Guo, MJ Meyer, TV Vo, X Wang, ...
Molecular BioSystems 10 (1), 9-17, 2014
Integrated network analysis reveals distinct regulatory roles of transcription factors and microRNAs
Y Guo, K Alexander, AG Clark, A Grimson, H Yu
RNA 22 (11), 1663-1672, 2016
Epigenetic promoter alterations in GI tumour immune-editing and resistance to immune checkpoint inhibition
R Sundar, KK Huang, V Kumar, K Ramnarayanan, D Demircioglu, Z Her, ...
Gut 71 (7), 1277-1288, 2022
SMuRF: portable and accurate ensemble prediction of somatic mutations
W Huang, YA Guo, K Muthukumar, P Baruah, MM Chang, ...
Bioinformatics 35 (17), 3157-3159, 2019
Regulatory enhancer profiling of mesenchymal-type gastric cancer reveals subtype-specific epigenomic landscapes and targetable vulnerabilities
SWT Ho, T Sheng, M Xing, WF Ooi, C Xu, R Sundar, KK Huang, Z Li, ...
Gut 72 (2), 226-241, 2023
Genomic and epigenomic EBF1 alterations modulate TERT expression in gastric cancer
M Xing, WF Ooi, J Tan, A Qamra, PH Lee, Z Li, C Xu, N Padmanabhan, ...
The Journal of Clinical Investigation 130 (6), 3005-3020, 2020
MutSpot: detection of non-coding mutation hotspots in cancer genomes
YA Guo, MM Chang, AJ Skanderup
NPJ genomic medicine 5 (1), 26, 2020
Integrative epigenomic and high-throughput functional enhancer profiling reveals determinants of enhancer heterogeneity in gastric cancer
T Sheng, SWT Ho, WF Ooi, C Xu, M Xing, N Padmanabhan, KK Huang, ...
Genome Medicine 13 (1), 1-25, 2021
Wnt1 silences chemokine genes in dendritic cells and induces adaptive immune resistance in lung adenocarcinoma. Nat Commun. 2019
D Kerdidani, P Chouvardas, AR Arjo, I Giopanou, G Ntaliarda, YA Guo
A randomized phase 2 trial of nivolumab versus nivolumab-ipilimumab combination in EGFR-mutant NSCLC
GGY Lai, JC Yeo, A Jain, S Zhou, M Pang, JJS Alvarez, NL Sim, AC Tan, ...
JTO Clinical and Research Reports 3 (12), 100416, 2022
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