| The role of androgen receptor mutations in prostate cancer progression GN Brooke, CL Bevan Current genomics 10 (1), 18-25, 2009 | 229 | 2009 |
| Gliotoxin is a dual inhibitor of farnesyltransferase and geranylgeranyltransferase I with antitumor activity against breast cancer in vivo DM Vigushin, N Mirsaidi, G Brooke, C Sun, P Pace, L Inman, CJ Moody, ... Medical oncology 21, 21-30, 2004 | 133 | 2004 |
| Revising the role of the androgen receptor in breast cancer FM Fioretti, A Sita-Lumsden, CL Bevan, GN Brooke Journal of molecular endocrinology 52 (3), R257-R265, 2014 | 115 | 2014 |
| Prohibitin, a protein downregulated by androgens, represses androgen receptor activity SC Gamble, D Chotai, M Odontiadis, DA Dart, GN Brooke, SM Powell, ... Oncogene 26 (12), 1757-1768, 2007 | 109 | 2007 |
| Mechanisms of androgen receptor activation in advanced prostate cancer: differential co-activator recruitment and gene expression GN Brooke, MG Parker, CL Bevan Oncogene 27 (21), 2941-2950, 2008 | 99 | 2008 |
| The antiandrogen enzalutamide downregulates TMPRSS2 and reduces cellular entry of SARS-CoV-2 in human lung cells DA Leach, A Mohr, ES Giotis, E Cil, AM Isac, LL Yates, WS Barclay, ... Nature Communications 12 (1), 4068, 2021 | 78 | 2021 |
| Structural and functional modelling of SARS-CoV-2 entry in animal models GN Brooke, F Prischi Scientific reports 10 (1), 15917, 2020 | 78 | 2020 |
| FUS/TLS is a novel mediator of androgen-dependent cell-cycle progression and prostate cancer growth GN Brooke, RL Culley, DA Dart, DJ Mann, L Gaughan, SR McCracken, ... Cancer research 71 (3), 914-924, 2011 | 75 | 2011 |
| Allosteric conversation in the androgen receptor ligand-binding domain surfaces S Grosdidier, LR Carbó, V Buzón, G Brooke, P Nguyen, JD Baxter, ... Molecular Endocrinology 26 (7), 1078-1090, 2012 | 73 | 2012 |
| Role of the HSP90-associated cochaperone p23 in enhancing activity of the androgen receptor and significance for prostate cancer V Reebye, L Querol Cano, DN Lavery, GN Brooke, SM Powell, D Chotai, ... Molecular endocrinology 26 (10), 1694-1706, 2012 | 53 | 2012 |
| The co-chaperone p23 promotes prostate cancer motility and metastasis LQ Cano, DN Lavery, S Sin, E Spanjaard, GN Brooke, JD Tilman, ... Molecular oncology 9 (1), 295-308, 2015 | 37 | 2015 |
| Reducing prohibitin increases histone acetylation, and promotes androgen independence in prostate tumours by increasing androgen receptor activation by adrenal androgens DA Dart, GN Brooke, A Sita-Lumsden, J Waxman, CL Bevan Oncogene 31 (43), 4588-4598, 2012 | 31 | 2012 |
| Circulating nucleic acids as biomarkers of prostate cancer A Sita-Lumsden, CE Fletcher, DA Dart, GN Brooke, J Waxman, CL Bevan Biomarkers in medicine 7 (6), 867-877, 2013 | 29 | 2013 |
| The role of the p90 ribosomal S6 kinase family in prostate cancer progression and therapy resistance R Cronin, GN Brooke, F Prischi Oncogene 40 (22), 3775-3785, 2021 | 28 | 2021 |
| MSC. sTRAIL has better efficacy than MSC. FL-TRAIL and in combination with AKTi blocks pro-metastatic cytokine production in prostate cancer cells A Mohr, T Chu, GN Brooke, RM Zwacka Cancers 11 (4), 568, 2019 | 26 | 2019 |
| Pyrazino [1, 2-a] indole-1, 4-diones, simple analogues of gliotoxin, as selective inhibitors of geranylgeranyltransferase I DM Vigushin, G Brooke, D Willows, RC Coombes, CJ Moody Bioorganic & medicinal chemistry letters 13 (21), 3661-3663, 2003 | 25 | 2003 |
| Characterisation of the androgen regulation of glycine N-methyltransferase in prostate cancer cells S Ottaviani, GN Brooke, C O'Hanlon-Brown, J Waxman, S Ali, L Buluwela Journal of molecular endocrinology 51 (3), 301-312, 2013 | 23 | 2013 |
| Mechanisms of androgen receptor repression in prostate cancer SM Powell, GN Brooke, HC Whitaker, V Reebye, SC Gamble, D Chotai, ... Biochemical Society Transactions 34 (6), 1124-1127, 2006 | 22 | 2006 |
| Assessing phototoxicity in a mammalian cell line: how low levels of blue light affect motility in PC3 cells RA Alghamdi, M Exposito-Rodriguez, PM Mullineaux, GN Brooke, ... Frontiers in cell and developmental biology 9, 738786, 2021 | 20 | 2021 |
| Antiandrogens Act as Selective Androgen Receptor Modulators at the Proteome Level in Prostate Cancer Cells*[S] GN Brooke, SC Gamble, MA Hough, S Begum, DA Dart, M Odontiadis, ... Molecular & Cellular Proteomics 14 (5), 1201-1216, 2015 | 20 | 2015 |
