| Mutations of protocadherin 19 in female epilepsy (PCDH19-FE) lead to allopregnanolone deficiency C Tan, C Shard, E Ranieri, K Hynes, DH Pham, D Leach, G Buchanan, ... Human molecular genetics 24 (18), 5250-5259, 2015 | 95 | 2015 |
| Stromal androgen receptor regulates the composition of the microenvironment to influence prostate cancer outcome DA Leach, EF Need, R Toivanen, AP Trotta, HM Palenthorpe, DJ Tamblyn, ... Oncotarget 6 (18), 16135, 2015 | 92 | 2015 |
| p53 controls expression of the DNA deaminase APOBEC3B to limit its potential mutagenic activity in cancer cells M Periyasamy, AK Singh, C Gemma, C Kranjec, R Farzan, DA Leach, ... Nucleic acids research 45 (19), 11056-11069, 2017 | 91 | 2017 |
| The antiandrogen enzalutamide downregulates TMPRSS2 and reduces cellular entry of SARS-CoV-2 in human lung cells DA Leach, A Mohr, ES Giotis, E Cil, AM Isac, LL Yates, WS Barclay, ... Nature Communications 12 (1), 4068, 2021 | 78 | 2021 |
| Androgen receptor-modulatory microRNAs provide insight into therapy resistance and therapeutic targets in advanced prostate cancer CE Fletcher, E Sulpice, S Combe, A Shibakawa, DA Leach, MP Hamilton, ... Oncogene 38 (28), 5700-5724, 2019 | 71 | 2019 |
| Stromal androgen receptor in prostate cancer development and progression DA Leach, G Buchanan Cancers 9 (1), 10, 2017 | 71 | 2017 |
| Inflammatory peroxidases promote breast cancer progression in mice via regulation of the tumour microenvironment V Panagopoulos, DA Leach, I Zinonos, V Ponomarev, G Licari, V Liapis, ... International journal of oncology 50 (4), 1191-1200, 2017 | 61 | 2017 |
| The unique transcriptional response produced by concurrent estrogen and progesterone treatment in breast cancer cells results in upregulation of growth factor pathways and … EF Need, LA Selth, AP Trotta, DA Leach, L Giorgio, MA O’Loughlin, ... BMC cancer 15, 1-17, 2015 | 39 | 2015 |
| Knockdown of the cochaperone SGTA results in the suppression of androgen and PI3K/Akt signaling and inhibition of prostate cancer cell proliferation AP Trotta, EF Need, LA Selth, S Chopra, CB Pinnock, DA Leach, ... International Journal of Cancer 133 (12), 2812-2823, 2013 | 37 | 2013 |
| Uncovering a new role for peroxidase enzymes as drivers of angiogenesis V Panagopoulos, I Zinonos, DA Leach, SJ Hay, V Liapis, A Zysk, ... The international journal of biochemistry & cell biology 68, 128-138, 2015 | 36 | 2015 |
| Hic-5 influences genomic and non-genomic actions of the androgen receptor in prostate myofibroblasts DA Leach, EF Need, AP Trotta, MJ Grubisha, DB DeFranco, G Buchanan Molecular and Cellular Endocrinology 384 (1-2), 185-199, 2014 | 33 | 2014 |
| Cell-lineage specificity and role of AP-1 in the prostate fibroblast androgen receptor cistrome DA Leach, V Panagopoulos, C Nash, C Bevan, AA Thomson, LA Selth, ... Molecular and cellular endocrinology 439, 261-272, 2017 | 30 | 2017 |
| Identification of transcription factor co-regulators that drive prostate cancer progression M Siddappa, SA Wani, MD Long, DA Leach, EA Mathé, CL Bevan, ... Scientific Reports 10 (1), 20332, 2020 | 26 | 2020 |
| Women in cancer thematic review: new roles for nuclear receptors in prostate cancer DA Leach, SM Powell, CL Bevan Endocrine-Related Cancer 23 (11), T85-T108, 2016 | 26 | 2016 |
| VDR activity is differentially affected by Hic-5 in prostate cancer and stromal cells JD Solomon, MD Heitzer, TT Liu, JH Beumer, RA Parise, DP Normolle, ... Molecular Cancer Research 12 (8), 1166-1180, 2014 | 25 | 2014 |
| Peroxidase enzymes inhibit osteoclast differentiation and bone resorption V Panagopoulos, V Liapis, I Zinonos, S Hay, DA Leach, W Ingman, ... Molecular and cellular endocrinology 440, 8-15, 2017 | 23 | 2017 |
| Androgen receptor and androgen-responsive gene FKBP5 are independent prognostic indicators for esophageal adenocarcinoma E Smith, HM Palethorpe, AR Ruszkiewicz, S Edwards, DA Leach, ... Digestive diseases and sciences 61, 433-443, 2016 | 22 | 2016 |
| AMPK activation protects against prostate cancer by inducing a catabolic cellular state L Penfold, A Woods, AE Pollard, J Arizanova, E Pascual-Navarro, ... Cell reports 42 (4), 2023 | 21 | 2023 |
| Roles of steroid receptors in the lung and COVID-19 DA Leach, GN Brooke, CL Bevan Essays in biochemistry 65 (6), 1025-1038, 2021 | 18 | 2021 |
| A non-coding RNA balancing act: miR-346-induced DNA damage is limited by the long non-coding RNA NORAD in prostate cancer CE Fletcher, L Deng, F Orafidiya, W Yuan, M Lorentzen, OW Cyran, ... Molecular Cancer 21 (1), 82, 2022 | 17 | 2022 |
