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Damien Leach
Damien Leach
Verifisert e-postadresse på imperial.ac.uk
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Mutations of protocadherin 19 in female epilepsy (PCDH19-FE) lead to allopregnanolone deficiency
C Tan, C Shard, E Ranieri, K Hynes, DH Pham, D Leach, G Buchanan, ...
Human molecular genetics 24 (18), 5250-5259, 2015
892015
Stromal androgen receptor regulates the composition of the microenvironment to influence prostate cancer outcome
DA Leach, EF Need, R Toivanen, AP Trotta, HM Palenthorpe, DJ Tamblyn, ...
Oncotarget 6 (18), 16135, 2015
882015
p53 controls expression of the DNA deaminase APOBEC3B to limit its potential mutagenic activity in cancer cells
M Periyasamy, AK Singh, C Gemma, C Kranjec, R Farzan, DA Leach, ...
Nucleic acids research 45 (19), 11056-11069, 2017
872017
The antiandrogen enzalutamide downregulates TMPRSS2 and reduces cellular entry of SARS-CoV-2 in human lung cells
DA Leach, A Mohr, ES Giotis, E Cil, AM Isac, LL Yates, WS Barclay, ...
Nature Communications 12 (1), 4068, 2021
682021
Stromal androgen receptor in prostate cancer development and progression
DA Leach, G Buchanan
Cancers 9 (1), 10, 2017
662017
Androgen receptor-modulatory microRNAs provide insight into therapy resistance and therapeutic targets in advanced prostate cancer
CE Fletcher, E Sulpice, S Combe, A Shibakawa, DA Leach, MP Hamilton, ...
Oncogene 38 (28), 5700-5724, 2019
622019
Inflammatory peroxidases promote breast cancer progression in mice via regulation of the tumour microenvironment
V Panagopoulos, DA Leach, I Zinonos, V Ponomarev, G Licari, V Liapis, ...
International journal of oncology 50 (4), 1191-1200, 2017
552017
The unique transcriptional response produced by concurrent estrogen and progesterone treatment in breast cancer cells results in upregulation of growth factor pathways and …
EF Need, LA Selth, AP Trotta, DA Leach, L Giorgio, MA O’Loughlin, ...
BMC cancer 15 (1), 1-17, 2015
392015
Knockdown of the cochaperone SGTA results in the suppression of androgen and PI3K/Akt signaling and inhibition of prostate cancer cell proliferation
AP Trotta, EF Need, LA Selth, S Chopra, CB Pinnock, DA Leach, ...
International Journal of Cancer 133 (12), 2812-2823, 2013
362013
Hic-5 influences genomic and non-genomic actions of the androgen receptor in prostate myofibroblasts
DA Leach, EF Need, AP Trotta, MJ Grubisha, DB DeFranco, G Buchanan
Molecular and cellular endocrinology 384 (1-2), 185-199, 2014
342014
Uncovering a new role for peroxidase enzymes as drivers of angiogenesis
V Panagopoulos, I Zinonos, DA Leach, SJ Hay, V Liapis, A Zysk, ...
The international journal of biochemistry & cell biology 68, 128-138, 2015
312015
Cell-lineage specificity and role of AP-1 in the prostate fibroblast androgen receptor cistrome
DA Leach, V Panagopoulos, C Nash, C Bevan, AA Thomson, LA Selth, ...
Molecular and cellular endocrinology 439, 261-272, 2017
292017
Women in cancer thematic review: new roles for nuclear receptors in prostate cancer
DA Leach, SM Powell, CL Bevan
Endocrine-Related Cancer 23 (11), T85-T108, 2016
252016
VDR activity is differentially affected by Hic-5 in prostate cancer and stromal cells
JD Solomon, MD Heitzer, TT Liu, JH Beumer, RA Parise, DP Normolle, ...
Molecular Cancer Research 12 (8), 1166-1180, 2014
242014
Androgen receptor and androgen-responsive gene FKBP5 are independent prognostic indicators for esophageal adenocarcinoma
E Smith, HM Palethorpe, AR Ruszkiewicz, S Edwards, DA Leach, ...
Digestive diseases and sciences 61, 433-443, 2016
222016
Identification of transcription factor co-regulators that drive prostate cancer progression
M Siddappa, SA Wani, MD Long, DA Leach, EA Mathé, CL Bevan, ...
Scientific Reports 10 (1), 20332, 2020
202020
Peroxidase enzymes inhibit osteoclast differentiation and bone resorption
V Panagopoulos, V Liapis, I Zinonos, S Hay, DA Leach, W Ingman, ...
Molecular and cellular endocrinology 440, 8-15, 2017
192017
Roles of steroid receptors in the lung and COVID-19
DA Leach, GN Brooke, CL Bevan
Essays in Biochemistry 65 (6), 1025-1038, 2021
152021
Myofibroblast androgen receptor expression determines cell survival in co-cultures of myofibroblasts and prostate cancer cells in vitro
HM Palethorpe, DA Leach, EF Need, PA Drew, E Smith
Oncotarget 9 (27), 19100, 2018
112018
A non-coding RNA balancing act: miR-346-induced DNA damage is limited by the long non-coding RNA NORAD in prostate cancer
CE Fletcher, L Deng, F Orafidiya, W Yuan, M Lorentzen, OW Cyran, ...
Molecular Cancer 21 (1), 82, 2022
102022
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Artikler 1–20