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Marte Innselset Flydal
Marte Innselset Flydal
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Phenylalanine hydroxylase: function, structure, and regulation
MI Flydal, A Martinez
IUBMB life 65 (4), 341-349, 2013
2202013
Structure of phenylalanine hydroxylase from Colwellia psychrerythraea 34H, a monomeric cold active enzyme with local flexibility around the active site and high overall stability
HKS Leiros, AL Pey, M Innselset, E Moe, I Leiros, IH Steen, A Martinez
Journal of Biological Chemistry 282 (30), 21973-21986, 2007
842007
Arc is a flexible modular protein capable of reversible self-oligomerization
C Myrum, A Baumann, HJ Bustad, MI Flydal, V Mariaule, S Alvira, ...
Biochemical Journal 468 (1), 145-158, 2015
742015
Structure of full-length human phenylalanine hydroxylase in complex with tetrahydrobiopterin
MI Flydal, M Alcorlo-Pagés, FG Johannessen, S Martínez-Caballero, ...
Proceedings of the National Academy of Sciences 116 (23), 11229-11234, 2019
572019
Brain catecholamine depletion and motor impairment in a Th knock-in mouse with type B tyrosine hydroxylase deficiency
G Korner, D Noain, M Ying, M Hole, MI Flydal, T Scherer, G Allegri, ...
Brain 138 (10), 2948-2963, 2015
412015
Stable preparations of tyrosine hydroxylase provide the solution structure of the full-length enzyme
MT Bezem, A Baumann, L Skjærven, R Meyer, P Kursula, A Martinez, ...
Scientific reports 6 (1), 30390, 2016
332016
Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation
MT Bueno-Carrasco, J Cuéllar, MI Flydal, C Santiago, TA Kråkenes, ...
Nature communications 13 (1), 74, 2022
302022
Arc self‐association and formation of virus‐like capsids are mediated by an N‐terminal helical coil motif
MS Eriksen, O Nikolaienko, EI Hallin, S Grødem, HJ Bustad, MI Flydal, ...
The FEBS journal 288 (9), 2930-2955, 2021
282021
Phenylalanine Hydroxylase from Legionella pneumophila Is a Thermostable Enzyme with a Major Functional Role in Pyomelanin Synthesis
MI Flydal, CH Chatfield, H Zheng, FF Gunderson, O Aubi, NP Cianciotto, ...
Public Library of Science 7 (9), e46209, 2012
282012
Regulation of tyrosine hydroxylase is preserved across different homo-and heterodimeric 14-3-3 proteins
S Ghorbani, A Fossbakk, A Jorge-Finnigan, MI Flydal, J Haavik, R Kleppe
Amino acids 48, 1221-1229, 2016
262016
Superstoichiometric binding of L-Phe to phenylalanine hydroxylase from Caenorhabditis elegans: evolutionary implications
MI Flydal, TC Mohn, AL Pey, J Siltberg-Liberles, K Teigen, A Martinez
Amino Acids 39, 1463-1475, 2010
192010
The Host-Pathogen interaction of Human Cyclophilin A and HIV-1 Vpr requires specific N-terminal and novel C-terminal domains
SMO Solbak, V Wray, O Horvli, AJ Raae, MI Flydal, P Henklein, ...
BMC structural biology 11 (1), 49, 2011
182011
Discovery of a Specific Inhibitor of Pyomelanin Synthesis in Legionella pneumophila
O Aubi, MI Flydal, H Zheng, L Skjærven, I Rekand, HKS Leiros, BE Haug, ...
Journal of medicinal chemistry 58 (21), 8402-8412, 2015
172015
Personalized medicine to improve treatment of dopa-responsive dystonia—a focus on tyrosine hydroxylase deficiency
G Nygaard, PD Szigetvari, AK Grindheim, P Ruoff, A Martinez, J Haavik, ...
Journal of Personalized Medicine 11 (11), 1186, 2021
112021
Inhibition of the human hsc70 system by small ligands as a potential anticancer approach
L Dublang, J Underhaug, MI Flydal, L Velasco-Carneros, JD Maréchal, ...
Cancers 13 (12), 2936, 2021
112021
Levalbuterol lowers the feedback inhibition by dopamine and delays misfolding and aggregation in tyrosine hydroxylase
MI Flydal, TA Kråkenes, MDS Tai, MPA Tran, K Teigen, A Martinez
Biochimie 183, 126-132, 2021
102021
New perspectives for pharmacological chaperoning treatment in methylmalonic aciduria cblB type
S Brasil, A Briso-Montiano, A Gámez, J Underhaug, MI Flydal, L Desviat, ...
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1864 (2), 640-648, 2018
102018
Differential scanning fluorimetry in the screening and validation of pharmacological chaperones for soluble and membrane proteins
SI Støve, MI Flydal, E Hausvik, J Underhaug, A Martinez
Protein Homeostasis Diseases, 329-341, 2020
82020
Characterization of the Cdc6 Homologues from the Euryarchaeon Thermoplasma acidophilum
GT Haugland, M Innselset, D Madern, NK Birkeland
The Open Biochemistry Journal 2, 129, 2008
62008
Structural and thermodynamic insight into phenylalanine hydroxylase from the human pathogen Legionella pneumophila
HKS Leiros, MI Flydal, A Martinez
FEBS Open bio 3, 370-378, 2013
52013
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Artikler 1–20