Kyle Hoehn
Kyle Hoehn
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Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance
WL Holland, JT Brozinick, LP Wang, ED Hawkins, KM Sargent, Y Liu, ...
Cell metabolism 5 (3), 167-179, 2007
Excess lipid availability increases mitochondrial fatty acid oxidative capacity in muscle: evidence against a role for reduced fatty acid oxidation in lipid-induced insulin …
N Turner, CR Bruce, SM Beale, KL Hoehn, T So, MS Rolph, GJ Cooney
Diabetes 56 (8), 2085-2092, 2007
Insulin resistance is a cellular antioxidant defense mechanism
KL Hoehn, AB Salmon, C Hohnen-Behrens, N Turner, AJ Hoy, ...
Proceedings of the National Academy of Sciences 106 (42), 17787-17792, 2009
Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B
S Stratford, KL Hoehn, F Liu, SA Summers
Journal of Biological Chemistry 279 (35), 36608-36615, 2004
Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth
JA Kashatus, A Nascimento, LJ Myers, A Sher, FL Byrne, KL Hoehn, ...
Molecular cell 57 (3), 537-551, 2015
Autophagy is required for exercise training‐induced skeletal muscle adaptation and improvement of physical performance
VA Lira, M Okutsu, M Zhang, NP Greene, RC Laker, DS Breen, KL Hoehn, ...
The FASEB Journal 27 (10), 4184-4193, 2013
Lipid mediators of insulin resistance
WL Holland, TA Knotts, JA Chavez, LP Wang, KL Hoehn, SA Summers
Nutrition reviews 65 (suppl_1), S39-S46, 2007
IRS1-independent defects define major nodes of insulin resistance
KL Hoehn, C Hohnen-Behrens, A Cederberg, LE Wu, N Turner, T Yuasa, ...
Cell metabolism 7 (5), 421-433, 2008
Mitochondrial division is requisite to RAS-induced transformation and targeted by oncogenic MAPK pathway inhibitors
MN Serasinghe, SY Wieder, TT Renault, R Elkholi, JJ Asciolla, JL Yao, ...
Molecular cell 57 (3), 521-536, 2015
Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein
D Park, CZ Han, MR Elliott, JM Kinchen, PC Trampont, S Das, S Collins, ...
Nature 477 (7363), 220-224, 2011
Pigment epithelium-derived factor contributes to insulin resistance in obesity
S Crowe, LE Wu, C Economou, SM Turpin, M Matzaris, KL Hoehn, ...
Cell metabolism 10 (1), 40-47, 2009
Exercise prevents maternal high-fat diet–induced hypermethylation of the Pgc-1α gene and age-dependent metabolic dysfunction in the offspring
RC Laker, TS Lillard, M Okutsu, M Zhang, KL Hoehn, JJ Connelly, Z Yan
Diabetes 63 (5), 1605-1611, 2014
A novel MitoTimer reporter gene for mitochondrial content, structure, stress, and damage in vivo
RC Laker, P Xu, KA Ryall, A Sujkowski, BM Kenwood, KH Chain, ...
Journal of Biological Chemistry 289 (17), 12005-12015, 2014
Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity
KL Hoehn, N Turner, MM Swarbrick, D Wilks, E Preston, Y Phua, H Joshi, ...
Cell metabolism 11 (1), 70-76, 2010
Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane
BM Kenwood, JL Weaver, A Bajwa, IK Poon, FL Byrne, BA Murrow, ...
Molecular metabolism 3 (2), 114-123, 2014
Regulator of fatty acid metabolism, acetyl coenzyme a carboxylase 1, controls T cell immunity
JE Lee, MC Walsh, KL Hoehn, DE James, EJ Wherry, Y Choi
The Journal of Immunology 192 (7), 3190-3199, 2014
CaMKII-mediated phosphorylation of the myosin motor Myo1c is required for insulin-stimulated GLUT4 translocation in adipocytes
MF Yip, G Ramm, M Larance, KL Hoehn, MC Wagner, M Guilhaus, ...
Cell metabolism 8 (5), 384-398, 2008
Opening of the mitochondrial permeability transition pore links mitochondrial dysfunction to insulin resistance in skeletal muscle
EP Taddeo, RC Laker, DS Breen, YN Akhtar, BM Kenwood, JA Liao, ...
Molecular metabolism 3 (2), 124-134, 2014
A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism
N Turner, XY Lim, HD Toop, B Osborne, AE Brandon, EN Taylor, ...
Nature communications 9 (1), 1-14, 2018
Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation
JDY Chow, RT Lawrence, ME Healy, JE Dominy, JA Liao, DS Breen, ...
Molecular metabolism 3 (4), 419-431, 2014
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