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Paul Savage
Paul Savage
General Surgery Resident, University of Toronto
Verifisert e-postadresse på mail.utoronto.ca
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The receptor tyrosine kinase AXL is required at multiple steps of the metastatic cascade during HER2-positive breast cancer progression
MA Goyette, S Duhamel, L Aubert, A Pelletier, P Savage, MP Thibault, ...
Cell reports 23 (5), 1476-1490, 2018
1412018
ERRα mediates metabolic adaptations driving lapatinib resistance in breast cancer
G Deblois, HW Smith, IS Tam, SP Gravel, M Caron, P Savage, DP Labbé, ...
Nature communications 7 (1), 12156, 2016
1182016
YAP-induced resistance of cancer cells to antitubulin drugs is modulated by a Hippo-independent pathway
Y Zhao, P Khanal, P Savage, YM She, TD Cyr, X Yang
Cancer research 74 (16), 4493-4503, 2014
972014
Epigenetic switch–induced viral mimicry evasion in chemotherapy-resistant breast cancer
G Deblois, SAM Tonekaboni, G Grillo, C Martinez, YI Kao, F Tai, I Ettayebi, ...
Cancer discovery 10 (9), 1312-1329, 2020
922020
Targeting EZH2 reactivates a breast cancer subtype-specific anti-metastatic transcriptional program
A Hirukawa, HW Smith, D Zuo, CR Dufour, P Savage, N Bertos, ...
Nature communications 9 (1), 2547, 2018
792018
A targetable EGFR-dependent tumor-initiating program in breast cancer
P Savage, A Blanchet-Cohen, T Revil, D Badescu, SMI Saleh, YC Wang, ...
Cell reports 21 (5), 1140-1149, 2017
762017
Dual MAPK inhibition is an effective therapeutic strategy for a subset of class II BRAF mutant melanomas
M Dankner, M Lajoie, D Moldoveanu, TT Nguyen, P Savage, S Rajkumar, ...
Clinical Cancer Research 24 (24), 6483-6494, 2018
662018
Lyn modulates Claudin-2 expression and is a therapeutic target for breast cancer liver metastasis
S Tabariès, MG Annis, BE Hsu, CE Tam, P Savage, M Park, PM Siegel
Oncotarget 6 (11), 9476, 2015
562015
Sumoylation of Krüppel-like factor 4 inhibits pluripotency induction but promotes adipocyte differentiation
S Tahmasebi, M Ghorbani, P Savage, K Yan, G Gocevski, L Xiao, L You, ...
Journal of Biological Chemistry 288 (18), 12791-12804, 2013
512013
The SUMO conjugating enzyme Ubc9 is required for inducing and maintaining stem cell pluripotency
S Tahmasebi, M Ghorbani, P Savage, G Gocevski, XJ Yang
Stem cells 32 (4), 1012-1020, 2014
412014
Activation of the pattern recognition receptor NOD1 augments colon cancer metastasis
HY Jiang, S Najmeh, G Martel, E MacFadden-Murphy, R Farias, P Savage, ...
Protein & cell 11 (3), 187-201, 2020
372020
STAT1 potentiates oxidative stress revealing a targetable vulnerability that increases phenformin efficacy in breast cancer
SP Totten, YK Im, E Cepeda Cañedo, O Najyb, A Nguyen, S Hébert, ...
Nature Communications 12 (1), 3299, 2021
342021
Incidence and predictors of postoperative ileus after loop ileostomy closure: a systematic review and meta-analysis
R Garfinkle, P Savage, M Boutros, T Landry, P Reynier, N Morin, ...
Surgical endoscopy 33, 2430-2443, 2019
342019
Chemogenomic profiling of breast cancer patient-derived xenografts reveals targetable vulnerabilities for difficult-to-treat tumors
P Savage, A Pacis, H Kuasne, L Liu, D Lai, A Wan, M Dankner, ...
Communications biology 3 (1), 310, 2020
302020
An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis
HW Smith, A Hirukawa, V Sanguin-Gendreau, I Nandi, CR Dufour, D Zuo, ...
Nature communications 10 (1), 2901, 2019
272019
Invasive growth associated with Cold-Inducible RNA-Binding Protein expression drives recurrence of surgically resected brain metastases
M Dankner, M Caron, T Al-Saadi, WQ Yu, V Ouellet, R Ezzeddine, ...
Neuro-oncology 23 (9), 1470-1480, 2021
242021
The effect of the American Joint Committee on Cancer eighth edition on breast cancer staging and prognostication
P Savage, N Yu, S Dumitra, S Meterissian
European Journal of Surgical Oncology 45 (10), 1817-1820, 2019
152019
DZ-2384 has a superior preclinical profile to taxanes for the treatment of triple-negative breast cancer and is synergistic with anti-CTLA-4 immunotherapy
C Bernier, A Soliman, M Gravel, M Dankner, P Savage, K Petrecca, ...
Anti-Cancer Drugs 29 (8), 774-785, 2018
142018
Canadian MD-Ph. D. Programs Produce Impactful Physician-Scientists: The McGill Experience
TE Zhou, PA Savage, MJ Eisenberg
Journal of Biomedical Education 2016, 1-4, 2016
132016
Co-dependency for MET and FGFR1 in basal triple-negative breast cancers
VYC Sung, JF Knight, RM Johnson, YE Stern, SM Saleh, P Savage, ...
NPJ Breast Cancer 7 (1), 36, 2021
102021
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Artikler 1–20