Jan Cools
Jan Cools
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Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
RL Levine, M Wadleigh, J Cools, BL Ebert, G Wernig, BJP Huntly, ...
Cancer cell 7 (4), 387-397, 2005
A Tyrosine Kinase Created by Fusion of the PDGFRA and FIP1L1 Genes as a Therapeutic Target of Imatinib in Idiopathic Hypereosinophilic Syndrome
J Cools, DJ DeAngelo, J Gotlib, EH Stover, RD Legare, J Cortes, J Kutok, ...
New England Journal of Medicine 348 (13), 1201-1214, 2003
The genetic basis of early T-cell precursor acute lymphoblastic leukaemia
J Zhang, L Ding, L Holmfeldt, G Wu, SL Heatley, D Payne-Turner, ...
Nature 481 (7380), 157-163, 2012
Fusion of TEL, the ETS-Variant Gene 6 (ETV6), to the Receptor-Associated Kinase JAK2 as a Result of t(9; 12) in a Lymphoid and t(9; 15; 12) in a Myeloid Leukemia
P Peeters, SD Raynaud, J Cools, I Wlodarska, J Grosgeorge, P Philip, ...
Blood, The Journal of the American Society of Hematology 90 (7), 2535-2540, 1997
Mechanisms of resistance to imatinib mesylate in gastrointestinal stromal tumors and activity of the PKC412 inhibitor against imatinib-resistant mutants
M Debiec-Rychter, J Cools, H Dumez, R Sciot, M Stul, N Mentens, ...
Gastroenterology 128 (2), 270-279, 2005
Germline loss-of-function mutations in SPRED1 cause a neurofibromatosis 1–like phenotype
H Brems, M Chmara, M Sahbatou, E Denayer, K Taniguchi, R Kato, ...
Nature genetics 39 (9), 1120-1126, 2007
Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia
C Graux, J Cools, C Melotte, H Quentmeier, A Ferrando, R Levine, ...
Nature genetics 36 (10), 1084-1089, 2004
Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia
K De Keersmaecker, ZK Atak, N Li, C Vicente, S Patchett, T Girardi, ...
Nature genetics 45 (2), 186-190, 2013
CHIC2 deletion, a surrogate for FIP1L1-PDGFRA fusion, occurs in systemic mastocytosis associated with eosinophilia and predicts response to imatinib mesylate therapy
A Pardanani, RP Ketterling, SR Brockman, HC Flynn, SF Paternoster, ...
Blood 102 (9), 3093-3096, 2003
Elevated serum tryptase levels identify a subset of patients with a myeloproliferative variant of idiopathic hypereosinophilic syndrome associated with tissue fibrosis, poor …
AD Klion, P Noel, C Akin, MA Law, DG Gilliland, J Cools, DD Metcalfe, ...
Blood 101 (12), 4660-4666, 2003
The FIP1L1-PDGFRα fusion tyrosine kinase in hypereosinophilic syndrome and chronic eosinophilic leukemia: implications for diagnosis, classification, and management
J Gotlib, J Cools, JM Malone III, SL Schrier, DG Gilliland, SE Coutré
Blood 103 (8), 2879-2891, 2004
Cytogenetics and molecular genetics of T-cell acute lymphoblastic leukemia: from thymocyte to lymphoblast
C Graux, J Cools, L Michaux, P Vandenberghe, A Hagemeijer
Leukemia 20 (9), 1496-1510, 2006
Efficacy of the kinase inhibitor SU11248 against gastrointestinal stromal tumor mutants refractory to imatinib mesylate
H Prenen, J Cools, N Mentens, C Folens, R Sciot, P Schöffski, ...
Clinical Cancer Research 12 (8), 2622-2627, 2006
The genetics and molecular biology of T-ALL
T Girardi, C Vicente, J Cools, K De Keersmaecker
Blood, The Journal of the American Society of Hematology 129 (9), 1113-1123, 2017
Meta-analysis of Neuroblastomas Reveals a Skewed ALK Mutation Spectrum in Tumors with MYCN Amplification
S De Brouwer, K De Preter, C Kumps, P Zabrocki, M Porcu, ...
Clinical cancer research 16 (17), 4353-4362, 2010
Identification of novel fusion partners of ALK, the anaplastic lymphoma kinase, in anaplastic large‐cell lymphoma and inflammatory myofibroblastic tumor
J Cools, I Wlodarska, R Somers, N Mentens, F Pedeutour, B Maes, ...
Genes, Chromosomes and Cancer 34 (4), 354-362, 2002
Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia
I Lahortiga, K De Keersmaecker, P Van Vlierberghe, C Graux, ...
Nature genetics 39 (5), 593-595, 2007
PKC412 overcomes resistance to imatinib in a murine model of FIP1L1-PDGFRα-induced myeloproliferative disease
J Cools, EH Stover, CL Boulton, J Gotlib, RD Legare, SM Amaral, ...
Cancer cell 3 (5), 459-469, 2003
Clinical and molecular features of FIP1L1-PDFGRA (+) chronic eosinophilic leukemias
P Vandenberghe, I Wlodarska, L Michaux, P Zachée, M Boogaerts, ...
Leukemia 18 (4), 734-742, 2004
The recurrent SET-NUP214 fusion as a new HOXA activation mechanism in pediatric T-cell acute lymphoblastic leukemia
P Van Vlierberghe, M van Grotel, J Tchinda, C Lee, HB Beverloo, ...
Blood, The Journal of the American Society of Hematology 111 (9), 4668-4680, 2008
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