Cystathionine-β-synthase: molecular regulation and pharmacological inhibition K Zuhra, F Augsburger, T Majtan, C Szabo Biomolecules 10 (5), 697, 2020 | 145 | 2020 |
Pharmacological induction of mesenchymal-epithelial transition via inhibition of H2S biosynthesis and consequent suppression of ACLY activity in colon cancer cells K Ascenção, N Dilek, F Augsburger, T Panagaki, K Zuhra, C Szabo Pharmacological Research 165, 105393, 2021 | 44 | 2021 |
Physiological concentrations of cyanide stimulate mitochondrial Complex IV and enhance cellular bioenergetics EB Randi, K Zuhra, L Pecze, T Panagaki, C Szabo Proceedings of the National Academy of Sciences 118 (20), e2026245118, 2021 | 37 | 2021 |
N-Acetylcysteine Serves as Substrate of 3-Mercaptopyruvate Sulfurtransferase and Stimulates Sulfide Metabolism in Colon Cancer Cells K Zuhra, CS Tomé, L Masi, G Giardina, G Paulini, F Malagrinò, E Forte, ... Cells 8 (8), 828, 2019 | 37 | 2019 |
Hydrogen sulfide oxidation: adaptive changes in mitochondria of SW480 colorectal cancer cells upon exposure to hypoxia F Malagrinò, K Zuhra, L Mascolo, D Mastronicola, JB Vicente, E Forte, ... Oxidative Medicine and Cellular Longevity 2019, 2019 | 35 | 2019 |
The two faces of cyanide: an environmental toxin and a potential novel mammalian gasotransmitter K Zuhra, C Szabo The FEBS journal 289 (9), 2481-2515, 2022 | 34 | 2022 |
Overproduction of hydrogen sulfide, generated by cystathionine β-synthase, disrupts brain wave patterns and contributes to neurobehavioral dysfunction in a rat model of down … T Panagaki, L Lozano-Montes, L Janickova, K Zuhra, MP Szabo, T Majtan, ... Redox Biology 51, 102233, 2022 | 32 | 2022 |
Hydrogen sulfide metabolism and signaling in the tumor microenvironment A Giuffrè, CS Tomé, DGF Fernandes, K Zuhra, JB Vicente Tumor Microenvironment: The Main Driver of Metabolic Adaptation, 335-353, 2020 | 32 | 2020 |
The multifaceted roles of sulfane sulfur species in cancer-associated processes K Zuhra, CS Tomé, E Forte, JB Vicente, A Giuffrè Biochimica et Biophysica Acta (BBA)-Bioenergetics 1862 (2), 148338, 2021 | 26 | 2021 |
Mechanism of cystathionine-β-synthase inhibition by disulfiram: The role of bis (N, N-diethyldithiocarbamate)-copper (II) K Zuhra, T Panagaki, EB Randi, F Augsburger, M Blondel, G Friocourt, ... Biochemical pharmacology 182, 114267, 2020 | 26 | 2020 |
The role of organosulfur compounds as Nrf2 activators and their antioxidant effects MC Egbujor, M Petrosino, K Zuhra, L Saso Antioxidants 11 (7), 1255, 2022 | 22 | 2022 |
H2S biogenesis by cystathionine beta-synthase: mechanism of inhibition by aminooxyacetic acid and unexpected role of serine M Petrosino, K Zuhra, J Kopec, A Hutchin, C Szabo, T Majtan Cellular and Molecular Life Sciences 79 (8), 438, 2022 | 16 | 2022 |
MPST sulfurtransferase maintains mitochondrial protein import and cellular bioenergetics to attenuate obesity A Katsouda, D Valakos, VS Dionellis, SI Bibli, I Akoumianakis, S Karaliota, ... Journal of Experimental Medicine 219 (7), e20211894, 2022 | 16 | 2022 |
Screening pyridine derivatives against human hydrogen sulfide-synthesizing enzymes by orthogonal methods K Zuhra, PMF Sousa, G Paulini, AR Lemos, Z Kalme, I Bisenieks, ... Scientific Reports 9 (1), 684, 2019 | 13 | 2019 |
Sequential accumulation of ‘driver’pathway mutations induces the upregulation of hydrogen-sulfide-producing enzymes in human colonic epithelial cell organoids K Ascenção, N Dilek, K Zuhra, K Módis, T Sato, C Szabo Antioxidants 11 (9), 1823, 2022 | 11 | 2022 |
Cytoglobin silencing promotes melanoma malignancy but sensitizes for ferroptosis and pyroptosis therapy response J De Backer, D Maric, K Zuhra, A Bogaerts, C Szabo, W Vanden Berghe, ... Antioxidants 11 (8), 1548, 2022 | 10 | 2022 |
Epigallocatechin gallate is a potent inhibitor of cystathionine beta-synthase: Structure-activity relationship and mechanism of action K Zuhra, M Petrosino, B Gupta, T Panagaki, M Cecconi, ... Nitric Oxide 128, 12-24, 2022 | 7 | 2022 |
Inhibition of the 3-mercaptopyruvate sulfurtransferase—Hydrogen sulfide system promotes cellular lipid accumulation G Casili, E Randi, T Panagaki, K Zuhra, M Petrosino, C Szabo Geroscience 44 (4), 2271-2289, 2022 | 7 | 2022 |
Human Cystathionine γ-Lyase Is Inhibited by s-Nitrosation: A New Crosstalk Mechanism between NO and H2S DGF Fernandes, J Nunes, CS Tomé, K Zuhra, JMF Costa, AMM Antunes, ... Antioxidants 10 (9), 1391, 2021 | 7 | 2021 |
Role of Cystathionine β-Synthase and 3-Mercaptopyruvate Sulfurtransferase in the Regulation of Proliferation, Migration, and Bioenergetics of Murine Breast Cancer Cells SS Santos, LOCP Rodrigues, V Martins, M Petrosino, K Zuhra, ... Antioxidants 12 (3), 647, 2023 | 5 | 2023 |