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Markus Huemer
Markus Huemer
Director of Protein Engineering, BSO at Micreos GmbH Switzerland
Verified email at micreos.com - Homepage
Title
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Cited by
Year
Antibiotic resistance and persistence—Implications for human health and treatment perspectives
M Huemer, S Mairpady Shambat, SD Brugger, AS Zinkernagel
EMBO reports 21 (12), e51034, 2020
3662020
Prolonged bacterial lag time results in small colony variants that represent a sub-population of persisters
C Vulin, N Leimer, M Huemer, M Ackermann, AS Zinkernagel
Nature communications 9 (1), 4074, 2018
1302018
Molecular reprogramming and phenotype switching in Staphylococcus aureus lead to high antibiotic persistence and affect therapy success
M Huemer, S Mairpady Shambat, J Bergada-Pijuan, S Söderholm, ...
Proceedings of the National Academy of Sciences 118 (7), e2014920118, 2021
672021
Targeting hidden pathogens: cell-penetrating enzybiotics eradicate intracellular drug-resistant Staphylococcus aureus
C Röhrig, M Huemer, D Lorgé, S Luterbacher, P Phothaworn, C Schefer, ...
MBio 11 (2), 10.1128/mbio. 00209-20, 2020
512020
Cloning, Purification and Characterization of the Collagenase ColA Expressed by Bacillus cereus ATCC 14579
CM Abfalter, E Schönauer, K Ponnuraj, M Huemer, G Gadermaier, C Regl, ...
PloS one 11 (9), e0162433, 2016
322016
Calcium binding protects E-cadherin from cleavage by Helicobacter pylori HtrA
TP Schmidt, C Goetz, M Huemer, G Schneider, S Wessler
Gut pathogens 8, 1-10, 2016
282016
Hyperinflammatory environment drives dysfunctional myeloid cell effector response to bacterial challenge in COVID-19
S Mairpady Shambat, A Gomez-Mejia, TA Schweizer, M Huemer, ...
PLoS pathogens 18 (1), e1010176, 2022
242022
Blunted sFasL signalling exacerbates TNF‐driven neutrophil necroptosis in critically ill COVID‐19 patients
TA Schweizer, S Mairpady Shambat, C Vulin, S Hoeller, C Acevedo, ...
Clinical & translational immunology 10 (12), e1357, 2021
202021
Engineering of long-circulating peptidoglycan hydrolases enables efficient treatment of systemic Staphylococcus aureus infection
AM Sobieraj, M Huemer, LV Zinsli, S Meile, AP Keller, C Röhrig, ...
MBio 11 (5), 10.1128/mbio. 01781-20, 2020
182020
Quantification of within-patient Staphylococcus aureus phenotypic heterogeneity as a proxy for the presence of persisters across clinical presentations
J Bär, M Boumasmoud, SM Shambat, C Vulin, M Huemer, TA Schweizer, ...
Clinical Microbiology and Infection 28 (7), 1022. e1-1022. e7, 2022
112022
Serine-threonine phosphoregulation by PknB and Stp contributes to quiescence and antibiotic tolerance in Staphylococcus aureus
M Huemer, S Mairpady Shambat, S Hertegonne, J Bergada-Pijuan, ...
Science Signaling 16 (766), eabj8194, 2023
72023
Neutrophil and monocyte dysfunctional effector response towards bacterial challenge in critically-ill COVID-19 patients
SM Shambat, A Gómez-Mejia, TA Schweizer, M Huemer, CC Chang, ...
bioRxiv, 2020.12. 01.406306, 2020
72020
Ser/Thr phospho-regulation by PknB and Stp mediates bacterial quiescence and antibiotic persistence in Staphylococcus aureus
M Huemer, SM Shambat, S Pereira, L Van Gestel, J Bergada-Pijuan, ...
BioRxiv, 2021.05. 06.442895, 2021
52021
Assessing antibiotic tolerance of Staphylococcus aureus derived directly from patients by the replica plating tolerance isolation system (REPTIS)
SC Herren, M Huemer, CT Acevedo, A Gómez-Mejia, F Andreoni, ...
Antimicrobial Agents and Chemotherapy 66 (1), e00967-21, 2022
42022
E-Cadherin orthologues as substrates for the serine protease high temperature requirement A (HtrA)
S Bernegger, E Hutterer, U Zarzecka, TP Schmidt, M Huemer, I Widlroither, ...
Biomolecules 12 (3), 356, 2022
22022
Blunted Fas signaling favors RIPK1-driven neutrophil necroptosis in critically ill COVID-19 patients
TA Schweizer, SM Shambat, C Vulin, S Hoeller, C Acevedo, M Huemer, ...
bioRxiv, 2021.03. 19.436166, 2021
22021
MEndoB, a chimeric lysin featuring a novel domain architecture and superior activity for the treatment of staphylococcal infections
C Roehrig, M Huemer, D Lorgé, F Arn, N Heinrich, L Selvakumar, ...
Mbio 15 (2), e02540-23, 2024
2024
Systemic application of bone-targeting peptidoglycan hydrolases as a novel treatment approach for staphylococcal bone infection
AP Keller, M Huemer, CC Chang, S Mairpady Shambat, C Bjurnemark, ...
Mbio 14 (5), e01830-23, 2023
2023
Alpha-toxin elicited CX3CL1-release via ADAM10 in Staphylococcus aureus pneumonia impairs bactericidal function of human monocytes
S Mairpady Shambat, P Chen, RM Barilla, M Huemer, J Snaell, A Welin, ...
bioRxiv, 2023.09. 17.554633, 2023
2023
Staphylococcus aureus Persister Formation as an Adaptive Response During Infection–Sleeping Through the War
M Huemer
University of Zurich, 2021
2021
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