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Ron Firestein
Ron Firestein
Director of Cancer Centre, Hudson Institute of Medicine/Monash Health
Verifisert e-postadresse på hudson.org.au
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Rb targets histone H3 methylation and HP1 to promoters
SJ Nielsen, R Schneider, UM Bauer, AJ Bannister, A Morrison, D O'Carroll, ...
Nature 412 (6846), 561-565, 2001
11562001
CDK8 is a colorectal cancer oncogene that regulates β-catenin activity
R Firestein, AJ Bass, SY Kim, IF Dunn, SJ Silver, I Guney, E Freed, ...
Nature 455 (7212), 547-551, 2008
7912008
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth
R Firestein, G Blander, S Michan, P Oberdoerffer, S Ogino, J Campbell, ...
PloS one 3 (4), e2020, 2008
7312008
Integrative genomic approaches identify IKBKE as a breast cancer oncogene
JS Boehm, JJ Zhao, J Yao, SY Kim, R Firestein, IF Dunn, SK Sjostrom, ...
Cell 129 (6), 1065-1079, 2007
7092007
Oncogenic ERBB3 mutations in human cancers
BS Jaiswal, NM Kljavin, EW Stawiski, E Chan, C Parikh, S Durinck, ...
Cancer cell 23 (5), 603-617, 2013
4002013
A novel tankyrase small-molecule inhibitor suppresses APC mutation–driven colorectal tumor growth
T Lau, E Chan, M Callow, J Waaler, J Boggs, RA Blake, S Magnuson, ...
Cancer research 73 (10), 3132-3144, 2013
3372013
Association of SET domain and myotubularin-related proteins modulates growth control
X Cui, ID Vivo, R Slany, A Miyamoto, R Firestein, ML Cleary
Nature genetics 18 (4), 331-337, 1998
2881998
Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function
EE Storm, S Durinck, F de Sousa E Melo, J Tremayne, N Kljavin, C Tan, ...
Nature 529 (7584), 97-100, 2016
2312016
CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer
ML McCleland, K Mesh, E Lorenzana, VS Chopra, E Segal, C Watanabe, ...
The Journal of clinical investigation 126 (2), 639-652, 2016
2242016
Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition
A Boudreau, HE Purkey, A Hitz, K Robarge, D Peterson, S Labadie, ...
Nature chemical biology 12 (10), 779-786, 2016
2102016
Integrated proteogenomic characterization across major histological types of pediatric brain cancer
F Petralia, N Tignor, B Reva, M Koptyra, S Chowdhury, D Rykunov, A Krek, ...
Cell 183 (7), 1962-1985. e31, 2020
2002020
An integrated genomic screen identifies LDHB as an essential gene for triple-negative breast cancer
ML McCleland, AS Adler, Y Shang, T Hunsaker, T Truong, D Peterson, ...
Cancer research 72 (22), 5812-5823, 2012
1902012
Transcriptional regulation of Wnt/β-catenin pathway in colorectal cancer
J Bian, M Dannappel, C Wan, R Firestein
Cells 9 (9), 2125, 2020
1692020
Targeting LGR5+ cells with an antibody-drug conjugate for the treatment of colon cancer
MR Junttila, W Mao, X Wang, BE Wang, T Pham, J Flygare, SF Yu, S Yee, ...
Science translational medicine 7 (314), 314ra186-314ra186, 2015
1592015
CDK8 expression in 470 colorectal cancers in relation to β‐catenin activation, other molecular alterations and patient survival
R Firestein, K Shima, K Nosho, N Irahara, Y Baba, E Bojarski, ...
International journal of cancer 126 (12), 2863-2873, 2010
1512010
Regulation of myotubularin-related (MTMR) 2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphatase
SA Kim, PO Vacratsis, R Firestein, ML Cleary, JE Dixon
Proceedings of the National Academy of Sciences 100 (8), 4492-4497, 2003
1492003
Set Domain-Dependent Regulation of Transcriptional Silencing and Growth Control by SUV39H1, a Mammalian Ortholog of Drosophila Su(var)3-9
R Firestein, X Cui, P Huie, ML Cleary
Molecular and Cellular Biology 20 (13), 4900-4909, 2000
1442000
CDK8 maintains tumor dedifferentiation and embryonic stem cell pluripotency
AS Adler, ML McCleland, T Truong, S Lau, Z Modrusan, TM Soukup, ...
Cancer research 72 (8), 2129-2139, 2012
1422012
SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer
K Nosho, K Shima, N Irahara, S Kure, R Firestein, Y Baba, S Toyoda, ...
Modern Pathology 22 (7), 922-932, 2009
1312009
Lactate dehydrogenase B is required for the growth of KRAS-dependent lung adenocarcinomas
ML McCleland, AS Adler, L Deming, E Cosino, L Lee, EM Blackwood, ...
Clinical Cancer Research 19 (4), 773-784, 2013
1282013
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