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Manale Karam (Doldur)
Manale Karam (Doldur)
PhD Oncology
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Enhanced differentiation of human pluripotent stem cells into pancreatic progenitors co-expressing PDX1 and NKX6. 1
B Memon, M Karam, S Al-Khawaga, EM Abdelalim
Stem cell research & therapy 9, 1-15, 2018
642018
Protein kinase D1 stimulates proliferation and enhances tumorigenesis of MCF-7 human breast cancer cells through a MEK/ERK-dependent signaling pathway
M Karam, C Legay, C Auclair, JM Ricort
Experimental cell research 318 (5), 558-569, 2012
562012
CD56 expression in breast cancer induces sensitivity to natural killer-mediated cytotoxicity by enhancing the formation of cytotoxic immunological synapse
G Taouk, O Hussein, M Zekak, A Abouelghar, Y Al-Sarraj, EM Abdelalim, ...
Scientific reports 9 (1), 8756, 2019
382019
Protein kinase C inhibitor Gö6976 but not Gö6983 induces the reversion of E-to N-cadherin switch and metastatic phenotype in melanoma: identification of the role of protein …
M Merzoug-Larabi, C Spasojevic, M Eymard, C Hugonin, C Auclair, ...
BMC cancer 17, 1-22, 2017
262017
Protein kinase D1 regulates ER α‐positive breast cancer cell growth response to 17β‐estradiol and contributes to poor prognosis in patients
M Karam, I Bieche, C Legay, S Vacher, C Auclair, JM Ricort
Journal of Cellular and Molecular Medicine 18 (12), 2536-2552, 2014
252014
PKD1 is a potential biomarker and therapeutic target in triple-negative breast cancer
C Spasojevic, E Marangoni, S Vacher, F Assayag, D Meseure, ...
Oncotarget 9 (33), 23208, 2018
192018
Scalable generation of mesenchymal stem cells and adipocytes from human pluripotent stem cells
M Karam, I Younis, NR Elareer, S Nasser, EM Abdelalim
Cells 9 (3), 710, 2020
142020
The β-carboline harmine induces actin dynamic remodeling and abrogates the malignant phenotype in tumorigenic cells
R Le Moigne, F Subra, M Karam, C Auclair
Cells 9 (5), 1168, 2020
102020
Prognostic values of the mRNA expression of natural killer receptor ligands and their association with clinicopathological features in breast cancer patients
A Abouelghar, R Hasnah, G Taouk, M Saad, M Karam
Oncotarget 9 (43), 27171, 2018
82018
Phosphatidylinositol 3-kinase and protein kinase D1 specifically cooperate to negatively regulate the insulin-like growth factor signaling pathway
M Karam, C Lassarre, C Legay, JM Ricort
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1823 (2), 558-569, 2012
72012
The β-carboline Harmine improves the therapeutic benefit of anti-PD1 in melanoma by increasing the MHC-I-dependent antigen presentation
MZ Noman, IA Bocci, M Karam, KV Moer, M Bosseler, A Kumar, ...
Frontiers in Immunology 13, 980704, 2022
52022
Expression of CD94 by ex vivo-differentiated NK cells correlates with the in vitro and in vivo acquisition of cytotoxic features
M Hasmim, N Khalife, Y Zhang, M Doldur, G Visentin, S Terry, ...
Oncoimmunology 6 (10), e1346763, 2017
42017
Is Sphingosine-1-Phosphate a Regulator of Tumor Vascular Functionality?
M Karam, A Ives, C Auclair
Cancers 14 (5), 1302, 2022
32022
Robust and highly efficient protocol for differentiation of human pluripotent stem cells into mesenchymal stem cells
M Karam, EM Abdelalim
Induced Pluripotent Stem (iPS) Cells: Methods and Protocols, 257-271, 2020
32020
Platelet-derived growth factor negatively regulates the insulin-like growth factor signaling pathway through the coordinated action of phosphatidylinositol 3-kinase and protein …
C Lassarre, C Legay, M Karam, JM Ricort
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1833 (6), 1367-1377, 2013
32013
The'Holy grail'in immuno-oncology: Ac bioscience sa is aiming to potentiate anti-Pd-1 therapy efficacy through tumor cell conditioning strategy
A Schläpfer, C Auclair, B Janji, M Karam, MZ Noman
Chimia 74 (10), 771-771, 2020
22020
Sphingosine-1-Phosphate as Lung and Cardiac Vasculature Protecting Agent in SARS-CoV-2 Infection
M Karam, C Auclair
International Journal of Molecular Sciences 24 (17), 13088, 2023
12023
Robust Differentiation of Human iPSCs into a Pure Population of Adipocytes to Study Adipocyte-Associated Disorders
M Aghadi, M Karam, EM Abdelalim
JoVE (Journal of Visualized Experiments), e63311, 2022
12022
Enhancement of differentiation of multipotent pancreatic β cell precursors from human embryonic stem cells
E Abdelalim, B Memon, M Karam, S Al-Khawaga
Qatar Foundation Annual Research Conference Proceedings 2018 (2), HBPP297, 2018
2018
In Vitro Mimicking of IL-15 Delivery through Trans-Presentation Is a Potent Driver of NK Cell Expansion and Effector Functions
G Pittari, M Karam, M Merhi, M Jalis, S Chouaib
Qatar Foundation Annual Research Conference Proceedings 2016 (1), HBPP2355, 2016
2016
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Artikler 1–20