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Lucía Chávez-Gutiérrez
Lucía Chávez-Gutiérrez
University of Leuven / VIB Center for Brain & Disease Research
Verified email at kuleuven.vib.be
Title
Cited by
Cited by
Year
The mechanism of γ‐secretase dysfunction in familial Alzheimer disease
L Chávez‐Gutiérrez, L Bammens, I Benilova, A Vandersteen, M Benurwar, ...
The EMBO journal 31 (10), 2261-2274, 2012
6022012
LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis
S Matta, K Van Kolen, R da Cunha, G van den Bogaart, W Mandemakers, ...
Neuron 75 (6), 1008-1021, 2012
3902012
Alzheimer’s-causing mutations shift Aβ length by destabilizing γ-secretase-Aβn interactions
M Szaruga, B Munteanu, S Lismont, S Veugelen, K Horré, M Mercken, ...
Cell 170 (3), 443-456. e14, 2017
2292017
Clinical phenotype and genetic associations in autosomal dominant familial Alzheimer’s disease: a case series
NS Ryan, JM Nicholas, PSJ Weston, Y Liang, T Lashley, R Guerreiro, ...
The Lancet Neurology 15 (13), 1326-1335, 2016
2172016
Qualitative changes in human γ-secretase underlie familial Alzheimer’s disease
M Szaruga, S Veugelen, M Benurwar, S Lismont, D Sepulveda-Falla, ...
Journal of Experimental Medicine 212 (12), 2003-2013, 2015
1722015
Contribution of presenilin transmembrane domains 6 and 7 to a water-containing cavity in the γ-secretase complex
A Tolia, L Chávez-Gutiérrez, B De Strooper
Journal of Biological Chemistry 281 (37), 27633-27642, 2006
1652006
Learning by failing: ideas and concepts to tackle γ-secretases in Alzheimer's disease and beyond
B De Strooper, L Chávez Gutiérrez
Annual review of pharmacology and toxicology 55, 419-437, 2015
1522015
Glu332 in the nicastrin ectodomain is essential for γ-secretase complex maturation but not for its activity
L Chávez-Gutiérrez, A Tolia, E Maes, T Li, PC Wong, B De Strooper
Journal of biological chemistry 283 (29), 20096-20105, 2008
1482008
Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP
FK Wiseman, LJ Pulford, C Barkus, F Liao, E Portelius, R Webb, ...
Brain 141 (8), 2457-2474, 2018
1262018
Familial Alzheimer’s disease mutations in presenilin generate amyloidogenic Aβ peptide seeds
S Veugelen, T Saito, TC Saido, L Chávez-Gutiérrez, B De Strooper
Neuron 90 (2), 410-416, 2016
1222016
Signature amyloid β profiles are produced by different γ-secretase complexes
H Acx, L Chávez-Gutiérrez, L Serneels, S Lismont, M Benurwar, N Elad, ...
Journal of Biological Chemistry 289 (7), 4346-4355, 2014
932014
Modification of γ‐secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease
FX Guix, T Wahle, K Vennekens, A Snellinx, L Chávez‐Gutiérrez, ...
EMBO molecular medicine 4 (7), 660-673, 2012
842012
The dynamic conformational landscape of γ-secretase
N Elad, B De Strooper, S Lismont, W Hagen, S Veugelen, M Arimon, ...
Journal of cell science 128 (3), 589-598, 2015
802015
Modulation of γ-and β-secretases as early prevention against Alzheimer’s disease
I Voytyuk, B De Strooper, L Chavez-Gutierrez
Biological psychiatry 83 (4), 320-327, 2018
662018
Genetic determinants of white matter hyperintensities and amyloid angiopathy in familial Alzheimer's disease
NS Ryan, GJ Biessels, L Kim, JM Nicholas, PA Barber, P Walsh, P Gami, ...
Neurobiology of aging 36 (12), 3140-3151, 2015
662015
Functional and Topological Analysis of Pen-2, the Fourth Subunit of the γ-Secretase Complex*♦
L Bammens, L Chávez-Gutiérrez, A Tolia, A Zwijsen, B De Strooper
Journal of Biological Chemistry 286 (14), 12271-12282, 2011
652011
Inhibition of β-secretase in vivo via antibody binding to unique loops (D and F) of BACE1
L Zhou, L Chávez-Gutiérrez, K Bockstael, R Sannerud, W Annaert, ...
Journal of biological chemistry 286 (10), 8677-8687, 2011
602011
Extracellular interface between APP and Nicastrin regulates Aβ length and response to γ‐secretase modulators
D Petit, M Hitzenberger, S Lismont, KM Zoltowska, NS Ryan, M Mercken, ...
The EMBO journal 38 (12), e101494, 2019
592019
Mechanisms of neurodegeneration—Insights from familial Alzheimer’s disease
L Chávez-Gutiérrez, M Szaruga
Seminars in Cell & Developmental Biology 105, 75-85, 2020
472020
Aβ profiles generated by Alzheimer’s disease causing PSEN1 variants determine the pathogenicity of the mutation and predict age at disease onset
D Petit, SG Fernández, KM Zoltowska, T Enzlein, NS Ryan, A O’Connor, ...
Molecular psychiatry 27 (6), 2821-2832, 2022
452022
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